LUMIPROBE-NEW (NIR) Fluorescent Dyes

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Although most fluorophophores operate in visible or ultraviolet parts of the spectrum, near infrared (NIR) area is a very promising for fluorescence detection and imaging.

In infrared, much less background fluorescence is observed on microarrays, and tissue samples. This makes NIR dyes an ideal choice for the cases where low background, and high signal-to-noise ratio is critical.

Cy7, Cy7.5 rigid linker

Biological tissues possess "near infrared window" of transparency above 700 nm (actual value depends on tissue type). This allows for in-depth imaging of organisms in real-time, non-destructive fashion. Labeling of a biomolecule (peptide, protein, or other) with NIR dye makes it possible to track it, and study distribution of the molecule in organism. This type of imaging is a great tool for life science and drug design.

Lumiprobe offers two near infrared fluorophores: Cy7, and Cy7.5.

The dyes are of cyanine class. Both possess high extinction coefficients. Internal polymethyne chain contains cyclohexane moiety to increase rigidity and quantum yield. Fluorescence quantum yield is thus improved by 20% comparatively to parent structures.

Near Infrared (NIR) Fluorescent Dyes